Synthesis of kojic acid derivatives as secondary binding site probes of d-amino acid oxidase

FAD ANALOGUES AS ACTIVE SITE PROBES OF Rhodotorula gracilis D-AMINO ACID OXIDASE

The wide range of chemical reactivity exhibited by flavoprotein enzymes is determined fundamentally by the nature of the protein moiety. Studies on the interactions of the isoalloxazine nucleus of flavin with the enzyme are therefore ~ important in understanding this reactivitYi flavin analogues are extremely useful probes for elucidating structure-function relationships (1, 2). We have used a ...

Nano silica sulfuric acid catalyzed synthesis of 2-substituted aryl (indolyl) kojic acid derivatives

Nano silica sulfuric acid as a solid acid, was described to be an effective catalyst for one-pot three-component reaction of kojic acid, aryl aldehydes and indoles for the preparation of 2-substituted aryl (indolyl) kojic acid derivatives. The catalyst was prepared by combination of chlorosulfonic acid to nano silica gel. The size of nanoparticles were observed with SEM.All prepared compounds w...

Kojic Acid Derivatives

Melanin is one of the most important pigments which exist ubiquitously from microorganisms to plants and animals. It is secreted by melanocyte cells and determines the color of skin and hair in mammalians. It protects the skin from photocarcinogenesis by absorbing UV sunlight and removing reactive oxygen species (ROS) (Gupta, 2006; Kim, 2005; Sapkota, 2011). It is formed by enzymatically cataly...

Nano silica sulfuric acid catalyzed synthesis of 2-substituted aryl (indolyl) kojic acid derivatives

Nano silica sulfuric acid as a solid acid, was described to be an effective catalyst for one-pot three-component reaction of kojic acid, aryl aldehydes and indoles for the preparation of 2-substituted aryl (indolyl) kojic acid derivatives. The catalyst was prepared by combination of chlorosulfonic acid to nano silica gel. The size of nanoparticles were observed with SEM.All prepared compounds w...

Astudyon D-amino-acid Oxidase